Cymantrene        conjugation modulates the intracellular distribution and induces high cytotoxicity of a cell-penetrating peptide

Ines Neundorf; Jan Hoyer; Katrin Splith; Robert Rennert; Harmel W. Peindy N’Dongo; Ulrich Schatzschneider

doi:10.1039/B812799A

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Cymantreneconjugation modulates the intracellular distribution and induces high cytotoxicity of a cell-penetrating peptide†‡

Ines Neundorf,*^a Jan Hoyer,^a Katrin Splith,^a Robert Rennert,^a Harmel W. Peindy N’Dongo^b and Ulrich Schatzschneider*^b

Author affiliations

* Corresponding authors

^a Institut für Biochemie, Universität Leipzig, Brüderstr. 34, Leipzig, Germany
E-mail: ines.neundorf@uni-leipzig.de
Fax: (+)49 341 97-36909

^b Lehrstuhl für Anorganische Chemie I-Bioanorganische Chemie, Ruhr-Univeristät Bochum NC 3/74, Universitätsstr. 150, Bochum, Germany
E-mail: ulrich.schatzschneider@rub.de
Fax: (+)49 234 32-14378

Abstract

The conjugation of cymantreneCpMn(CO)₃ to cell-penetrating peptide hCT(18-32)-k7 alters the intracellular distribution in MCF-7 cells compared to the unmodified peptide, as visualized by fluorescence microscopy, and leads to an increased nuclear accumulation; the peptide and cymantrene compound themselves are not toxic, but the bioconjugate shows a significant cytotoxicity with an IC₅₀ value of 36 μmol l⁻¹.

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Supplementary files

Synthesis of compound 1 PDF (223K)

Article information

DOI: https://doi.org/10.1039/B812799A
Article type: Communication
Submitted: 25 Jul 2008
Accepted: 12 Sep 2008
First published: 26 Sep 2008

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Chem. Commun., 2008, 5604-5606

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Cymantrene conjugation modulates the intracellular distribution and induces high cytotoxicity of a cell-penetrating peptide

I. Neundorf, J. Hoyer, K. Splith, R. Rennert, H. W. Peindy N’Dongo and U. Schatzschneider, Chem. Commun., 2008, 5604 DOI: 10.1039/B812799A

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