Issue 47, 2008

Caesium fluoride-promoted Stille coupling reaction: an efficient synthesis of 9Z-retinoic acid and its analogues using a practical building block

Abstract

A highly efficient and rapid total synthesis of 9Z-retinoic acid was accomplished by caesium fluoride-promoted Stille coupling reaction; using a common building block, 9Z-retinoic acid analogues were also prepared by the same method without isomerisation of the Z-double bond.

Graphical abstract: Caesium fluoride-promoted Stille coupling reaction: an efficient synthesis of 9Z-retinoic acid and its analogues using a practical building block

Supplementary files

Article information

Article type
Communication
Submitted
07 Aug 2008
Accepted
23 Sep 2008
First published
23 Oct 2008

Chem. Commun., 2008, 6330-6332

Caesium fluoride-promoted Stille coupling reaction: an efficient synthesis of 9Z-retinoic acid and its analogues using a practical building block

T. Okitsu, K. Iwatsuka and A. Wada, Chem. Commun., 2008, 6330 DOI: 10.1039/B813760A

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