Issue 2, 2009
From the journal:

Chemical Communications

Enzyme-catalyzed synthesis of isosteric phosphono-analogues of sugar nucleotides†

Stephen A. Beaton,a   Malcolm P. Huestis,b   Ali Sadeghi-Khomami,bc   Neil R. Thomasc  and  David L. Jakeman*ab  

* Corresponding authors

a Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, Canada

b College of Pharmacy, Burbidge Building, Dalhousie University, 5968 College St., Halifax, Nova Scotia, Canada
E-mail: david.jakeman@dal.ca
Fax: 1 902 494 1396
Tel: 1 902 494 7159

c School of Chemistry, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, England

Abstract

Efficient enzymatic syntheses of isosteric phosphono analogues of sugar nucleotides have been accomplished using a thymidylyltransferase.

Graphical abstract: Enzyme-catalyzed synthesis of isosteric phosphono-analogues of sugar nucleotides

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Article information

DOI
https://doi.org/10.1039/B808078J
Article type
Communication
Submitted
13 May 2008
Accepted
20 Oct 2008
First published
18 Nov 2008

Chem. Commun., 2009, 238-240

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Enzyme-catalyzed synthesis of isosteric phosphono-analogues of sugar nucleotides

S. A. Beaton, M. P. Huestis, A. Sadeghi-Khomami, N. R. Thomas and D. L. Jakeman, Chem. Commun., 2009, 238 DOI: 10.1039/B808078J

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