Issue 7, 2009
From the journal:

Chemical Communications

A general approach for the non-stop solid phase synthesis of TAC-scaffolded loops towards protein mimics containing discontinuous epitopes†

Cristina Chamorro,a   John A. W. Kruijtzer,a   Marina Farsaraki,a   Jan Balzarinib  and  Rob M. J. Liskamp*a  

* Corresponding authors

a Medicinal Chemistry & Chemical Biology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, P.O. Box 80082, Utrecht, The Netherlands
E-mail: r.m.j.liskamp@uu.nl
Web: http://www.pharm.uu.nl/medchem
Fax: +31 30-2536655
Tel: +31 30-2537396

b Rega Institute for Medical Research, K.U. Leuven, Minderbroederstraat 10, Leuven, Belgium

Abstract

In this Communication, the access to three different peptide loops attached to a small triazacyclophane (TAC) scaffold molecule for the mimicry of discontinuous epitopes present in, for example, antibodies is described for the first time.

Graphical abstract: A general approach for the non-stop solid phase synthesis of TAC-scaffolded loops towards protein mimics containing discontinuous epitopes

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Article information

DOI
https://doi.org/10.1039/B817357E
Article type
Communication
Submitted
03 Oct 2008
Accepted
11 Nov 2008
First published
17 Dec 2008

Chem. Commun., 2009, 821-823

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A general approach for the non-stop solid phase synthesis of TAC-scaffolded loops towards protein mimics containing discontinuous epitopes

C. Chamorro, J. A. W. Kruijtzer, M. Farsaraki, J. Balzarini and R. M. J. Liskamp, Chem. Commun., 2009, 821 DOI: 10.1039/B817357E

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