Issue 14, 2009
From the journal:

Chemical Communications

Reversible stability switching of a hairpin DNAvia a photo-responsive linker unit†‡

Li Wu,a   Kazuya Koumotoa  and  Naoki Sugimoto*ab  

* Corresponding authors

a Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 8-9-1, Okamoto, Higashinada-ku, Kobe 658-8501, Japan
E-mail: sugimoto@konan-u.ac.jp
Fax: +81-78-435-2766
Tel: +81-78-435-2485

b Department of Chemistry, Faculty of Science and Engineering, Konan University, 8-9-1, Okamoto, Higashinada-ku, Kobe 658-8501, Japan

Abstract

We have designed and synthesized a novel photo-responsive linker unit, 4,4′-bis(hydroxymethyl)-azobenzene, which was introduced to the loop oligonucleotide in a DNA hairpin and was able to reversibly control the stability of the whole hairpin structure via UV or visible light irradiation.

Graphical abstract: Reversible stability switching of a hairpin DNAvia a photo-responsive linker unit

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Article information

DOI
https://doi.org/10.1039/B819643E
Article type
Communication
Submitted
05 Nov 2008
Accepted
03 Feb 2009
First published
23 Feb 2009

Chem. Commun., 2009, 1915-1917

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Reversible stability switching of a hairpin DNAvia a photo-responsive linker unit

L. Wu, K. Koumoto and N. Sugimoto, Chem. Commun., 2009, 1915 DOI: 10.1039/B819643E

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