Issue 5, 2009
From the journal:

Chemical Communications

Towards quorum-quenching catalytic antibodies†

Prashant B. Kapadnis,a   Evan Hall,b   Madeleine Ramstedt,a   Warren R. J. D. Galloway,a   Martin Welchb  and  David R. Spring*a  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: drspring@ch.cam.ac.uk

b Department of Biochemistry, University of Cambridge, Cambridge, UK

Abstract

The development of a novel method to attenuate bacterial virulence is reported, which is based upon the use of designed transition-state analogues to select human catalytic antibodies capable of degrading bacterial quorum-sensing molecules.

Graphical abstract: Towards quorum-quenching catalytic antibodies

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Article information

DOI
https://doi.org/10.1039/B819819E
Article type
Communication
Submitted
06 Nov 2008
Accepted
28 Nov 2008
First published
11 Dec 2008

Chem. Commun., 2009, 538-540

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Towards quorum-quenching catalytic antibodies

P. B. Kapadnis, E. Hall, M. Ramstedt, W. R. J. D. Galloway, M. Welch and D. R. Spring, Chem. Commun., 2009, 538 DOI: 10.1039/B819819E

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