Issue 24, 2009

Polymeric nanomedicine for cancer MR imaging and drug delivery

Abstract

Multifunctional nanomedicine is emerging as a highly integrated platform that allows for molecular diagnosis, targeted drug delivery, and simultaneous monitoring and treatment of cancer. Advances in polymer and materials science are critical for the successful development of these multi-component nanocomposites in one particulate system with such a small size confinement (<200 nm). Currently, several nanoscopic therapeutic and diagnostic systems have been translated into clinical practice. In this feature article, we will provide an up-to-date review on the development and biomedical applications of nanocomposite materials for cancer diagnosis and therapy. An overview of each functional component, i.e.polymer carriers, MR imaging agents, and therapeutic drugs, will be presented. Integration of different functional components will be illustrated in several highlighted examples to demonstrate the synergy of the multifunctional nanomedicine design.

Graphical abstract: Polymeric nanomedicine for cancer MR imaging and drug delivery

Article information

Article type
Feature Article
Submitted
08 Dec 2008
Accepted
03 Feb 2009
First published
10 Mar 2009

Chem. Commun., 2009, 3497-3510

Polymeric nanomedicine for cancer MR imaging and drug delivery

C. Khemtong, C. W. Kessinger and J. Gao, Chem. Commun., 2009, 3497 DOI: 10.1039/B821865J

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