Issue 21, 2009
From the journal:

Chemical Communications

Bile acid-based polyaminocarboxylate conjugates as targeted antitumor agents†

Hyun-Soon Chong,*a   Hyun A. Song,a   Xiang Ma,a   Sooyoun Lim,a   Xiang Suna  and  Santosh B. Mhaskea  

* Corresponding authors

a Chemistry Division, Biological, Chemical, and Physical Sciences Department, Illinois Institute of Technology, Chicago, USA
E-mail: chong@iit.edu
Fax: +1 312-567-3494
Tel: +1 312-567-3235

Abstract

Bile acid–polyaminocarboxylate conjugates containing NE3TA, a potential iron chelator displayed significant cytotoxicities in both HeLa and HT29 colon cancer cells, and cholic acid–NE3TA attached to an organic fluorophore was shown to enter the HT29 cancer cells.

Graphical abstract: Bile acid-based polyaminocarboxylate conjugates as targeted antitumor agents

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Article information

DOI
https://doi.org/10.1039/B823000E
Article type
Communication
Submitted
22 Dec 2008
Accepted
19 Mar 2009
First published
01 May 2009

Chem. Commun., 2009, 3011-3013

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Bile acid-based polyaminocarboxylate conjugates as targeted antitumor agents

H. Chong, H. A. Song, X. Ma, S. Lim, X. Sun and S. B. Mhaske, Chem. Commun., 2009, 3011 DOI: 10.1039/B823000E

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