Issue 16, 2009
From the journal:

Chemical Communications

Efficient and convenient preparation of 3-aryl-2,2-dimethylpropanoates viaNegishi coupling†

Young-Shin Kwak,*a   Aaron D. Kanter,a   Bing Wangb  and  Yugang Liuc  

* Corresponding authors

a Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 100 Technology Sq., Cambridge, USA
E-mail: youngshin.kwak@novartis.com
Fax: +1-617-871-7044
Tel: +1-617-871-7538

b Analytical Sciences, Institutes for BioMedical Research, 100 Technology Sq., Cambridge, USA

c Chemical Development, Novartis Pharmaceutical Corporation, One Health Plaza, East Hanover, USA

Abstract

An efficient and convenient Negishi coupling protocol was developed for the preparation of 3-aryl-2,2-dimethylpropanoates providing easy access to key pharmaceutical intermediates that often require multi-step synthesis using conventional enolate chemistry.

Graphical abstract: Efficient and convenient preparation of 3-aryl-2,2-dimethylpropanoates viaNegishi coupling

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Article information

DOI
https://doi.org/10.1039/B902779C
Article type
Communication
Submitted
10 Feb 2009
Accepted
05 Mar 2009
First published
23 Mar 2009

Chem. Commun., 2009, 2145-2147

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Efficient and convenient preparation of 3-aryl-2,2-dimethylpropanoates viaNegishi coupling

Y. Kwak, A. D. Kanter, B. Wang and Y. Liu, Chem. Commun., 2009, 2145 DOI: 10.1039/B902779C

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