Cell-based in vivo dual imaging probes using genetically expressed tags and chemical contrast agents

Yuki Hasegawa; Aki Honda; Keitaro Umezawa; Yusuke Niino; Kotaro Oka; Tomohiro Chiba; Sadakazu Aiso; Akihiro Tanimoto; Daniel Citterio; Koji Suzuki

doi:10.1039/B904055B

Cell-based in vivo dual imaging probes using genetically expressed tags and chemical contrast agents†‡

Yuki Hasegawa,^a Aki Honda,^a Keitaro Umezawa,^a Yusuke Niino,^b Kotaro Oka,^b Tomohiro Chiba,^c Sadakazu Aiso,^c Akihiro Tanimoto,^d Daniel Citterio^a and Koji Suzuki*^a

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* Corresponding authors

^a Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Kohoku-ku, Yokohama, Japan
E-mail: suzuki@applc.keio.ac.jp
Fax: +81 45 566-1566

^b Department of Bioscience and Informatics, Faculty of Science and Technology, Keio University, Kohoku-ku, Yokohama, Japan

^c Department of Anatomy, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan

^d Department of Diagnostic Radiology, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan

Abstract

We report a method for specifically labelling the surface of cells with two kinds of chemical probes (near-infrared (NIR) fluorescent probes and magnetic resonance (MR) imaging probes) via two genetically expressed tags, and demonstrate the application for in vitro and in vivo dual imaging.

Chemical Communications

Cell-based in vivo dual imaging probes using genetically expressed tags and chemical contrast agents†‡

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Cell-based in vivo dual imaging probes using genetically expressed tags and chemical contrast agents

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