Issue 26, 2009
From the journal:

Chemical Communications

Base and copper(i) catalyzed Mannich, alkynehydroamination cascades for the direct synthesis of 2-methylenepyrrolidines†

Hai-Fei Wang,a   Ting Yang,b   Peng-Fei Xu*a  and  Darren J. Dixon*c  

* Corresponding authors

a State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P.R. China
E-mail: xupf@lzu.edu.cn
Fax: +86 931 8915557
Tel: +86 931 8912281

b School of Chemistry, The University of Manchester, Oxford Road, Manchester, UK

c Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, UK
E-mail: Darren.Dixon@chem.ox.ac.uk
Fax: +44 (0)1865 285002
Tel: +44 (0)1865 275648

Abstract

An efficient, simple-to-perform, one-pot reaction cascade to 2-methylenepyrrolidines from p-toluenesulfonyl protected imines and propargylated malonates under a combination of base and copper(I) catalysis is reported.

Graphical abstract: Base and copper(i) catalyzed Mannich, alkyne hydroamination cascades for the direct synthesis of 2-methylenepyrrolidines

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Article information

DOI
https://doi.org/10.1039/B905629G
Article type
Communication
Submitted
20 Mar 2009
Accepted
11 May 2009
First published
01 Jun 2009

Chem. Commun., 2009, 3916-3918

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Base and copper(I) catalyzed Mannich, alkyne hydroamination cascades for the direct synthesis of 2-methylenepyrrolidines

H. Wang, T. Yang, P. Xu and D. J. Dixon, Chem. Commun., 2009, 3916 DOI: 10.1039/B905629G

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