Issue 24, 2009
From the journal:

Chemical Communications

Efficient three-component one-pot synthesis of fully substituted pyridin-2(1H)-ones via tandem Knoevenagel condensation–ring-opening of cyclopropane–intramolecular cyclization†

Fushun Liang,*a   Xin Cheng,a   Jing Liua  and  Qun Liua  

* Corresponding authors

a Department of Chemistry, Northeast Normal University, Changchun 130024, China
E-mail: liangfs112@nenu.edu.cn
Fax: +86 431-8509-9759

Abstract

An efficient synthesis of fully substituted pyridin-2(1H)-ones was developed via three-component one-pot reactions of readily available 1-acetyl-1-carbamoyl cyclopropanes, malononitrile and cyclic secondary amines.

Graphical abstract: Efficient three-component one-pot synthesis of fully substituted pyridin-2(1H)-ones via tandem Knoevenagel condensation–ring-opening of cyclopropane–intramolecular cyclization

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Article information

DOI
https://doi.org/10.1039/B905742K
Article type
Communication
Submitted
23 Mar 2009
Accepted
24 Apr 2009
First published
13 May 2009

Chem. Commun., 2009, 3636-3638

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Efficient three-component one-pot synthesis of fully substituted pyridin-2(1H)-ones via tandem Knoevenagel condensation–ring-opening of cyclopropane–intramolecular cyclization

F. Liang, X. Cheng, J. Liu and Q. Liu, Chem. Commun., 2009, 3636 DOI: 10.1039/B905742K

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