Issue 37, 2009

Synthesis of a monophosphoryl lipid A derivative and its conjugation to a modified form of a tumor-associated carbohydrateantigen GM3

Abstract

An efficient synthesis of a derivative of monophosphoryl lipid A suitable for coupling to various structures for the construction of glycoconjugate vaccines and its conjugation with an N-modified form of the tumor-associated antigen GM3 is presented.

Graphical abstract: Synthesis of a monophosphoryl lipid A derivative and its conjugation to a modified form of a tumor-associated carbohydrate antigen GM3

Supplementary files

Article information

Article type
Communication
Submitted
14 Apr 2009
Accepted
10 Aug 2009
First published
27 Aug 2009

Chem. Commun., 2009, 5536-5537

Synthesis of a monophosphoryl lipid A derivative and its conjugation to a modified form of a tumor-associated carbohydrate antigen GM3

Q. Wang, J. Xue and Z. Guo, Chem. Commun., 2009, 5536 DOI: 10.1039/B907351E

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