Issue 36, 2009
From the journal:

Chemical Communications

Screening for reactive metabolites using electro-optical arrays featuring human liver cytosol and microsomal enzyme sources and DNA†

Linlin Zhao,a   John B. Schenkmanb  and  James F. Rusling*ab  

* Corresponding authors

a Department of Chemistry, University of Connecticut, 55 N. Eagleville Rd, Storrs, USA
E-mail: james.rusling@uconn.edu

b Department of Cell Biology, University of Connecticut, Farmington, USA

Abstract

We demonstrate for the first time the combination of human liver cytosol and microsomal enzyme sources into an electro-optical array to screen for reactive metabolites produced in multi-enzyme metabolic processes.

Graphical abstract: Screening for reactive metabolites using electro-optical arrays featuring human liver cytosol and microsomal enzyme sources and DNA

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DOI
https://doi.org/10.1039/B909372A
Article type
Communication
Submitted
12 May 2009
Accepted
04 Aug 2009
First published
17 Aug 2009

Chem. Commun., 2009, 5386-5388

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Screening for reactive metabolites using electro-optical arrays featuring human liver cytosol and microsomal enzyme sources and DNA

L. Zhao, J. B. Schenkman and J. F. Rusling, Chem. Commun., 2009, 5386 DOI: 10.1039/B909372A

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