Issue 45, 2009
From the journal:

Chemical Communications

Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous†

Jacqueline A. I. Smith,a   Jingxin Wang,a   Sao-Mai Nguyen-Mau,b   Vincent Leeb  and  Herman O. Sintim*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of Maryland, College Park, USA
E-mail: hsintim@umd.edu

b Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, USA

Abstract

C1-alkyl AI-2 analogues do not induce bioluminescence in V. harveyi on their own but enhance the bioluminescence induced by AI-2 in a synergistic fashion. A new facile synthesis of AI-2 facilitates the synthesis of a diverse set of AI-2 analogues and biological screening suggests that receptors that are involved in the synergistic bioluminescence production in V. harveyi are promiscuous.

Graphical abstract: Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous

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Article information

DOI
https://doi.org/10.1039/B909666C
Article type
Communication
Submitted
15 May 2009
Accepted
21 Sep 2009
First published
13 Oct 2009

Chem. Commun., 2009, 7033-7035

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Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous

J. A. I. Smith, J. Wang, S. Nguyen-Mau, V. Lee and H. O. Sintim, Chem. Commun., 2009, 7033 DOI: 10.1039/B909666C

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