Issue 41, 2009
From the journal:

Chemical Communications

A general electrochemical method for label-free screening of protein–small molecule interactions†

Kevin J. Cash,a   Francesco Ricci‡b  and  Kevin W. Plaxco*bc  

* Corresponding authors

a Department of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, USA

b Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, USA
E-mail: kwp@chem.ucsb.edu

c Program in Biomolecular Science and Engineering, University of California, Santa Barbara, Santa Barbara, USA

Abstract

Here we report a versatile method by which the interaction between a protein and a small molecule, and the disruption of that interaction by competition with other small molecules, can be monitored electrochemically directly in complex sample matrices.

Graphical abstract: A general electrochemical method for label-free screening of protein–small molecule interactions

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Article information

DOI
https://doi.org/10.1039/B911558G
Article type
Communication
Submitted
12 Jun 2009
Accepted
30 Jul 2009
First published
28 Aug 2009

Chem. Commun., 2009, 6222-6224

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A general electrochemical method for label-free screening of protein–small molecule interactions

K. J. Cash, F. Ricci and K. W. Plaxco, Chem. Commun., 2009, 6222 DOI: 10.1039/B911558G

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