Issue 41, 2009
From the journal:

Chemical Communications

Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid β peptide†

W. Mei Kok,abc   Denis B. Scanlon,ac   John A. Karas,c   Luke A. Miles,cd   Deborah J. Tew,bc   Michael W. Parker,cd   Kevin J. Barnhambc  and  Craig A. Hutton*ac  

* Corresponding authors

a School of Chemistry, The University of Melbourne, Parkville, Australia
E-mail: chutton@unimelb.edu.au
Fax: +61 3 9347 8124
Tel: +61 3 8344 2393

b Department of Pathology, The University of Melbourne, Parkville, Australia

c Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Australia

d Biota Structural Biology Laboratory, St. Vincent’s Institute of Medical Research, 9 Princes Street, Fitzroy, Australia

Abstract

Covalently cross-linked homodimeric Aβ peptides have been prepared by solid-phase peptide synthesis by exploiting ‘site–site interactions’, and exhibit substantially increased oligomerisation and fibrillisation properties compared with the corresponding monomers.

Graphical abstract: Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid β peptide

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Article information

DOI
https://doi.org/10.1039/B912784D
Article type
Communication
Submitted
29 Jun 2009
Accepted
10 Aug 2009
First published
01 Sep 2009

Chem. Commun., 2009, 6228-6230

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Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid β peptide

W. M. Kok, D. B. Scanlon, J. A. Karas, L. A. Miles, D. J. Tew, M. W. Parker, K. J. Barnham and C. A. Hutton, Chem. Commun., 2009, 6228 DOI: 10.1039/B912784D

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