Issue 42, 2009
From the journal:

Chemical Communications

New reactions of 2-methylenetetrahydropyrans. A three component coupling protocol for the synthesis of tetrahydropyranyl ketides†

Guohua Liang,a   Laura J. Batemana  and  Nancy I. Totah*a  

* Corresponding authors

a Department of Chemistry, Syracuse University, Syracuse, USA
E-mail: ntotah@syr.edu
Fax: +1 315 443 4070
Tel: +1 315 443 2657

Abstract

Three component coupling of a 2-methylenetetrahydropyran, an activated aldehyde or ketone and a secondary nucleophile provides an efficient preparation of tetrahydropyranyl ketides, a unit common to many complex natural products.

Graphical abstract: New reactions of 2-methylenetetrahydropyrans. A three component coupling protocol for the synthesis of tetrahydropyranyl ketides

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Article information

DOI
https://doi.org/10.1039/B916190B
Article type
Communication
Submitted
07 Aug 2009
Accepted
02 Sep 2009
First published
23 Sep 2009

Chem. Commun., 2009, 6457-6459

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New reactions of 2-methylenetetrahydropyrans. A three component coupling protocol for the synthesis of tetrahydropyranyl ketides

G. Liang, L. J. Bateman and N. I. Totah, Chem. Commun., 2009, 6457 DOI: 10.1039/B916190B

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