Issue 44, 2009
From the journal:

Chemical Communications

A novel anti-cancer bifunctional platinum drug candidate with dual DNA binding and histone deacetylase inhibitory activity†

Darren Griffith,a   Maria P. Morganb  and  Celine J. Marmion*a  

* Corresponding authors

a Centre for Synthesis and Chemical Biology, Department of Pharmaceutical & Medicinal Chemistry, Royal College of Surgeons in Ireland (RCSI), 123 St. Stephen’s Green, Dublin 2, Ireland
E-mail: cmarmion@rcsi.ie
Fax: +353 1 4022168
Tel: +353 1 4022161

b Department of Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland (RCSI), 123 St. Stephen’s Green, Dublin 2, Ireland

Abstract

The successful design and synthesis of a novel multifunctional platinum drug candidate with DNA binding, histone deacetylase inhibitory activity and enhanced selectivity for cancer cells are described.

Graphical abstract: A novel anti-cancer bifunctional platinum drug candidate with dual DNA binding and histone deacetylase inhibitory activity

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Article information

DOI
https://doi.org/10.1039/B916715C
Article type
Communication
Submitted
14 Aug 2009
Accepted
14 Sep 2009
First published
12 Oct 2009

Chem. Commun., 2009, 6735-6737

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A novel anti-cancer bifunctional platinum drug candidate with dual DNA binding and histone deacetylase inhibitory activity

D. Griffith, M. P. Morgan and C. J. Marmion, Chem. Commun., 2009, 6735 DOI: 10.1039/B916715C

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