Issue 44, 2009
From the journal:

Chemical Communications

Optimized DNA-targeting using triplex forming C5-alkynyl functionalized LNA†

Sujay P. Sau,a   Pawan Kumar,ab   Brooke A. Anderson,a   Michael E. Østergaard,a   Lee Deobald,c   Andrzej Paszczynski,c   Pawan K. Sharmab  and  Patrick J. Hrdlicka*a  

* Corresponding authors

a Dept. of Chemistry, Univ. of Idaho, USA
E-mail: hrdlicka@uidaho.edu
Fax: +1 208 885 6173
Tel: +1 208 885 0108

b Dept. of Chemistry, Kurukshetra University, Kurukshetra 136119, India

c Environmental Biotechnology Institute, Univ. of Idaho, USA

Abstract

Triplex forming oligonucleotides (TFOs) modified with C5-alkynyl functionalized LNA (locked nucleic acid) monomers display extraordinary thermal affinity toward double stranded DNA targets, excellent discrimination of Hoogsteen-mismatched targets, and high stability against 3′-exonucleases.

Graphical abstract: Optimized DNA-targeting using triplex forming C5-alkynyl functionalized LNA

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Article information

DOI
https://doi.org/10.1039/B917312A
Article type
Communication
Submitted
21 Aug 2009
Accepted
17 Sep 2009
First published
12 Oct 2009

Chem. Commun., 2009, 6756-6758

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Optimized DNA-targeting using triplex forming C5-alkynyl functionalized LNA

S. P. Sau, P. Kumar, B. A. Anderson, M. E. Østergaard, L. Deobald, A. Paszczynski, P. K. Sharma and P. J. Hrdlicka, Chem. Commun., 2009, 6756 DOI: 10.1039/B917312A

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