Issue 22, 2009
From the journal:

Organic & Biomolecular Chemistry

Synthesis of functionalized H-pyrazolo[5,1-a]isoquinolines via sequential reactions of N′-(2-alkynylbenzylidene)hydrazides†

Zhiyuan Chen,a   Mingchao Su,a   Xingxin Yua  and  Jie Wu*ab  

* Corresponding authors

a Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, China
E-mail: jie_wu@fudan.edu.cn
Fax: +86 (0)21 6510 2412
Tel: +86 (0)21 5566 4619

b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai, China

Abstract

Diversity-oriented synthesis of functionalized H-pyrazolo[5,1-a]isoquinolines via sequential reactions of N′-(2-alkynylbenzylidene)hydrazide is described. Bromine-mediated electrophilic cyclization, Ag-catalyzed alkyne nucleophilic addition, and palladium-catalyzed cross-coupling reaction were involved in the transformation.

Graphical abstract: Synthesis of functionalized H-pyrazolo[5,1-a]isoquinolines via sequential reactions of N′-(2-alkynylbenzylidene)hydrazides

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Article information

DOI
https://doi.org/10.1039/B914265G
Article type
Paper
Submitted
16 Jul 2009
Accepted
18 Aug 2009
First published
16 Sep 2009

Org. Biomol. Chem., 2009,7, 4641-4646

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Synthesis of functionalized H-pyrazolo[5,1-a]isoquinolines via sequential reactions of N′-(2-alkynylbenzylidene)hydrazides

Z. Chen, M. Su, X. Yu and J. Wu, Org. Biomol. Chem., 2009, 7, 4641 DOI: 10.1039/B914265G

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