Heteromeric double helix formation by cross-hybridization of chloro-and fluoro-substituted quinoline oligoamides

Abstract

Oligoamides of 8-chloroquinoline have been synthesized and shown to assemble into double helical dimers both in solution and in the solid state, and to undergo cross-hybridization with 8-fluoroquinoline oligoamide analogues; the handedness of these double helices can be controlled via chiral residues.