Issue 2, 2010
From the journal:

Chemical Communications

Spontaneous and reversible self-assembly of a polypeptide fragment of insulin-like growth factor bindingprotein-2 into fluorescent nanotubular structures†

Monalisa Swain,ab   R. Thirupathi,abc   B. Krishnarjuna,a   Erin M. Eaton,d   Megan M. Kibbey,d   Steven A. Rosenzweigd  and  Hanudatta S. Atreya*a  

* Corresponding authors

a NMR Research Centre, Indian Institute of Science, Bangalore-560012, India
E-mail: hsatreya@sif.iisc.ernet.in
Fax: +91-80-23601550
Tel: +91-80-22933302

b Solid State & Structural Chemistry Unit, IISc, Bangalore-560012, India

c Nanoscience Initiative, IISc, Bangalore-560012, India

d Department of Cell and Molecular Pharmacology, Medical University of South Carolina, Charleston SC 29425, USA

Abstract

In this communication, we report the spontaneous and reversible in vitro self-assembly of a polypeptide fragment derived from the C-terminal domain of Insulin-like Growth Factor Binding Protein (IGFBP-2) into soluble nanotubular structures several micrometres long via a mechanism involving inter-molecular disulfide bonds and exhibiting enhanced fluorescence.

Graphical abstract: Spontaneous and reversible self-assembly of a polypeptide fragment of insulin-like growth factor binding protein-2 into fluorescent nanotubular structures

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Article information

DOI
https://doi.org/10.1039/B915775A
Article type
Communication
Submitted
31 Jul 2009
Accepted
26 Oct 2009
First published
12 Nov 2009

Chem. Commun., 2010,46, 216-218

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Spontaneous and reversible self-assembly of a polypeptide fragment of insulin-like growth factor binding protein-2 into fluorescent nanotubular structures

M. Swain, R. Thirupathi, B. Krishnarjuna, E. M. Eaton, M. M. Kibbey, S. A. Rosenzweig and H. S. Atreya, Chem. Commun., 2010, 46, 216 DOI: 10.1039/B915775A

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