Issue 1, 2010
From the journal:

Chemical Communications

Multimodal cell imaging by ruthenium polypyridyl labelled cell penetrating peptides†

Lynda Cosgrave,a   Marc Devocelle,b   Robert J. Forsterb  and  Tia E. Keyes*a  

* Corresponding authors

a National Bioimaging Platform, National Centre for Sensor Research, The School of Chemical Sciences, Dublin City University, Dublin 9, Ireland
E-mail: tia.keyes@dcu.ie

b Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephen’s Green, Dublin 2, Ireland

Abstract

The capacity of ruthenium polypyridyl complexes as probes for combined confocal luminescence and resonance Raman imaging, enabled by their large Stokes shift, is demonstrated for a novel membrane sensitive Ru(II) polypyridyl peptide. Confocal luminescence and resonance Raman imaging provides complementary information about the membrane phospholipid regions of the cell and the location of the dye within the cell.

Graphical abstract: Multimodal cell imaging by ruthenium polypyridyl labelled cell penetrating peptides

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Article information

DOI
https://doi.org/10.1039/B918611E
Article type
Communication
Submitted
09 Sep 2009
Accepted
06 Nov 2009
First published
19 Nov 2009

Chem. Commun., 2010,46, 103-105

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Multimodal cell imaging by ruthenium polypyridyl labelled cell penetrating peptides

L. Cosgrave, M. Devocelle, R. J. Forster and T. E. Keyes, Chem. Commun., 2010, 46, 103 DOI: 10.1039/B918611E

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