An enzymatic route to 5-deoxy-5-[18F]fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging

Mayca Onega; Juozas Domarkas; Hai Deng; Lutz F. Schweiger; Timothy A. D. Smith; Andrew E. Welch; Christophe Plisson; Antony D. Gee; David O’Hagan

doi:10.1039/B919364B

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An enzymatic route to 5-deoxy-5-[¹⁸F]fluoro-d-ribose, a [¹⁸F]-fluorinated sugar for PET imaging†

Mayca Onega,^ab Juozas Domarkas,^b Hai Deng,^c Lutz F. Schweiger,^b Timothy A. D. Smith,^b Andrew E. Welch,^b Christophe Plisson,^d Antony D. Gee^d and David O’Hagan*^a

Author affiliations

* Corresponding authors

^a University of St Andrews, School of Chemistry and Centre for Biomolecular Sciences, North Haugh, St Andrews, Fife, UK
E-mail: do1@st-andrews.ac.uk
Fax: +44 01334 463800
Tel: +44 01334 467171

^b John Mallard Scottish PET Centre, School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK

^c UK Marine Biodiscovery Centre, Department of Chemistry, Meston Walk, University of Aberdeen, Aberdeen, UK

^d GSK Clinical Imaging Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK

Abstract

An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5-[¹⁸F]fluororibose, a novel [¹⁸F]-fluorinated sugar suitable for positron emission tomography (PET) applications.

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Article information

DOI: https://doi.org/10.1039/B919364B
Article type: Communication
Submitted: 17 Sep 2009
Accepted: 20 Oct 2009
First published: 10 Nov 2009

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Chem. Commun., 2010,46, 139-141

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An enzymatic route to 5-deoxy-5-[¹⁸F]fluoro-D-ribose, a [¹⁸F]-fluorinated sugar for PET imaging

M. Onega, J. Domarkas, H. Deng, L. F. Schweiger, T. A. D. Smith, A. E. Welch, C. Plisson, A. D. Gee and D. O’Hagan, Chem. Commun., 2010, 46, 139 DOI: 10.1039/B919364B

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