Issue 6, 2010
From the journal:

Chemical Communications

Enantiomerically pure β-phenylalanine analogues from α–β-phenylalanine mixtures in a single reactive extraction step†

Bastiaan J. V. Verkuijl,a   Wiktor Szymański,ab   Bian Wu,b   Adriaan J. Minnaard,*a   Dick B. Janssen,*b   Johannes G. de Vries*ac  and  Ben L. Feringa*a  

* Corresponding authors

a Organic and Molecular Inorganic Chemistry, University of Groningen, Nijenborgh 4, Groningen, The Netherlands
E-mail: a.j.minnaard@rug.nl, b.l.feringa@rug.nl

b Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, Groningen, The Netherlands
E-mail: d.b.janssen@rug.nl

c DSM Pharmaceutical Products, Innovative Synthesis & Catalysis P.O. Box 18, MD Geleen, The Netherlands
E-mail: hans-jg.vries-de@dsm.com

Abstract

An efficient and selective method for the extraction of α-amino acids in preference over their β-isomers using PdCl2(PPh3)2 was discovered, which enables the separation of product mixtures obtained in the enantioselective enzymatic formation of β-amino acids.

Graphical abstract: Enantiomerically pure β-phenylalanine analogues from α–β-phenylalanine mixtures in a single reactive extraction step

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Article information

DOI
https://doi.org/10.1039/B921661H
Article type
Communication
Submitted
16 Oct 2009
Accepted
12 Nov 2009
First published
04 Dec 2009

Chem. Commun., 2010,46, 901-903

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Enantiomerically pure β-phenylalanine analogues from α–β-phenylalanine mixtures in a single reactive extraction step

B. J. V. Verkuijl, W. Szymański, B. Wu, A. J. Minnaard, D. B. Janssen, J. G. de Vries and B. L. Feringa, Chem. Commun., 2010, 46, 901 DOI: 10.1039/B921661H

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