Issue 13, 2010
From the journal:

Chemical Communications

Stereoselective synthesis of configurationally stable functionalized ethano-bridged Tröger bases†

Christophe Michon,a   Ankit Sharma,a   Gérard Bernardinelli,b   Eric Francottec  and  Jérôme Lacour*a  

* Corresponding authors

a Department of Organic Chemistry, Quai Ernest Ansermet 30, Ch-1211 Geneva 4, Switzerland
E-mail: jerome.lacour@unige.ch
Fax: +41 22 379 3215

b Laboratoire de Cristallographie, University of Geneva, Quai Ernest Ansermet 24, CH-1211 Geneva 4, Switzerland

c Global Discovery Chemistry, Novartis Institutes for Biomedical Research, WKL-122.P.25 Postfach, CH-4002 Basel, Switzerland

Abstract

New functionalized ethano-bridged Tröger bases are readily prepared using a simple alkylation/rearrangement sequence which affords configurationally stable derivatives as single stereoisomers (de > 96%).

Graphical abstract: Stereoselective synthesis of configurationally stable functionalized ethano-bridged Tröger bases

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Article information

DOI
https://doi.org/10.1039/B925065D
Article type
Communication
Submitted
30 Nov 2009
Accepted
13 Feb 2010
First published
25 Feb 2010

Chem. Commun., 2010,46, 2206-2208

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Stereoselective synthesis of configurationally stable functionalized ethano-bridged Tröger bases

C. Michon, A. Sharma, G. Bernardinelli, E. Francotte and J. Lacour, Chem. Commun., 2010, 46, 2206 DOI: 10.1039/B925065D

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