Issue 16, 2010
From the journal:

Chemical Communications

A new chemo-enzymatic route to chiral 2-hydroxy-4-phenylbutyrates by combining lactonase-mediated resolution with hydrogenation over Pd/C†

Bing Chen,a   Hai-Feng Yin,b   Zhen-Sheng Wang,b   Jia-Ying Liua  and  Jian-He Xu*a  

* Corresponding authors

a Laboratory of Biocatalysis and Bioprocessing, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China
E-mail: jianhexu@ecust.edu.cn
Fax: +86-21-64250840

b PepTech (Shanghai) Pharmaceutical Co., Ltd, Building #4, Lane 388 Yindu Road, Shanghai 200231, P. R. China

Abstract

A new chemo-enzymatic route to both isomers of 2-hydroxy-4-phenylbutyric acid is reported. The key step is the lactonase-catalyzed hydrolysis of cis- and trans-2-hydroxy-4-phenyl-4-butyrolactones followed by hydrogenation over Pd/C to afford optically pure 2-hydroxy-4-phenylbutyric acid.

Graphical abstract: A new chemo-enzymatic route to chiral 2-hydroxy-4-phenylbutyrates by combining lactonase-mediated resolution with hydrogenation over Pd/C

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Article information

DOI
https://doi.org/10.1039/B925402A
Article type
Communication
Submitted
02 Dec 2009
Accepted
03 Feb 2010
First published
25 Feb 2010

Chem. Commun., 2010,46, 2754-2756

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A new chemo-enzymatic route to chiral 2-hydroxy-4-phenylbutyrates by combining lactonase-mediated resolution with hydrogenation over Pd/C

B. Chen, H. Yin, Z. Wang, J. Liu and J. Xu, Chem. Commun., 2010, 46, 2754 DOI: 10.1039/B925402A

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