Issue 26, 2010
From the journal:

Chemical Communications

Identification of natural product Fonsecin B as a stabilizing ligand of c-mycG-quadruplexDNA by high-throughput virtual screening†

Ho-Man Lee,‡a   Daniel Shiu-Hin Chan,‡a   Fang Yang,a   Ho-Yu Lam,a   Siu-Cheong Yan,a   Chi-Ming Che,a   Dik-Lung Ma§*ab  and  Chung-Hang Leung§*a  

* Corresponding authors

a Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong
E-mail: duncanl@hku.hk

b Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
E-mail: edmondma@hkbu.edu.hk

Abstract

Fonsecin B has been identified as stabilizing ligand of c-myc G-quadruplex DNA using high-throughput virtual screening of a natural product database, and inhibited Taq polymerase-mediated DNA extension in vitro through stabilization of the G-quadruplex secondary structure.

Graphical abstract: Identification of natural product Fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening

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Article information

DOI
https://doi.org/10.1039/B926359D
Article type
Communication
Submitted
14 Dec 2009
Accepted
17 Mar 2010
First published
09 Apr 2010

Chem. Commun., 2010,46, 4680-4682

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Identification of natural product Fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening

H. Lee, D. S. Chan, F. Yang, H. Lam, S. Yan, C. Che, D. Ma and C. Leung, Chem. Commun., 2010, 46, 4680 DOI: 10.1039/B926359D

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