Near infrared-fluorescent and magnetic resonance imaging molecular probe with high T1 relaxivity for in vivo multimodal imaging

Kevin Guo; Mikhail Y. Berezin; Jie Zheng; Walter Akers; Franck Lin; Bao Teng; Olga Vasalatiy; Amir Gandjbakhche; Gary L. Griffiths; Samuel Achilefu

doi:10.1039/C000536C

Near infrared-fluorescent and magnetic resonance imaging molecular probe with high T₁ relaxivity for in vivo multimodal imaging†

Kevin Guo,^a Mikhail Y. Berezin,^a Jie Zheng,^a Walter Akers,^a Franck Lin,^b Bao Teng,^c Olga Vasalatiy,^c Amir Gandjbakhche,^d Gary L. Griffiths^c and Samuel Achilefu*^abe

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* Corresponding authors

^a Department of Radiology, Washington University, St. Louis, USA
E-mail: achilefus@mir.wustl.edu
Fax: 314-747-5191
Tel: 314-362-8599

^b Department of Biomedical Engineering, Washington University, St. Louis, USA

^c Imaging Probe Development Center, NHLBI, National Institutes of Health, Bethesda, USA

^d Eunice Shriver NICHD, National Institutes of Health, Bethesda, USA

^e Department of Biochemistry & Molecular Biophysics, Washington University, St. Louis, USA

Abstract

A new gadolinium chelating NIR fluorescent molecular probe increases T₁ relaxivity of water protons, facilitating combined optical and magnetic resonance imaging.

Chemical Communications

Near infrared-fluorescent and magnetic resonance imaging molecular probe with high T₁ relaxivity for in vivo multimodal imaging†

Abstract

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Near infrared-fluorescent and magnetic resonance imaging molecular probe with high T₁ relaxivity for in vivo multimodal imaging

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