Issue 16, 2010

Organocatalyzed enantioselective one-pot three-component access to indoloquinolizidines by a Michael addition–Pictet–Spengler sequence

Abstract

The enantioselective three-component Michael addition–Pictet–Spengler sequence of β-ketoesters 1, α,β-unsaturated aldehydes 2 and tryptamines 4 represents a facile and rapid one-pot access to highly substituted indoloquinolizidines in moderate to excellent yields and good to excellent enantioselectivities.

Graphical abstract: Organocatalyzed enantioselective one-pot three-component access to indoloquinolizidines by a Michael addition–Pictet–Spengler sequence

Supplementary files

Article information

Article type
Communication
Submitted
25 Jan 2010
Accepted
25 Feb 2010
First published
19 Mar 2010

Chem. Commun., 2010,46, 2733-2735

Organocatalyzed enantioselective one-pot three-component access to indoloquinolizidines by a Michael addition–Pictet–Spengler sequence

X. Wu, X. Dai, L. Nie, H. Fang, J. Chen, Z. Ren, W. Cao and G. Zhao, Chem. Commun., 2010, 46, 2733 DOI: 10.1039/C001512A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements