Issue 26, 2010
From the journal:

Chemical Communications

Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5′-monophosphate catalyzed by orotidine 5′-monophosphate decarboxylase†

Yuen-Jen Wu,a   Chen-Chieh Liao,a   Cheng-Hung Jen,a   Yu-Chiao Shiha  and  Tun-Cheng Chien*a  

* Corresponding authors

a Department of Chemistry, National Taiwan Normal University, No.88, Sec.4, Ting-Zhou Road, Taipei, Taiwan
E-mail: tcchien@ntnu.edu.tw
Fax: +886 2-29324249
Tel: +886 2-77346126

Abstract

The reactions of 6-cyano-1,3-dimethyluracil have been studied as chemical models to illustrate the mechanism for the transformation of 6-cyanouridine 5′-monophosphate (6-CN-UMP) to barbiturate ribonucleoside 5′-monophosphate (BMP) catalyzed by orotidine 5′-monophosphate decarboxylase (ODCase). The results suggest that the Asp residue in the ODCase active site plays the role of a general base in the transformation.

Graphical abstract: Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5′-monophosphate catalyzed by orotidine 5′-monophosphate decarboxylase

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Article information

DOI
https://doi.org/10.1039/C001865A
Article type
Communication
Submitted
27 Jan 2010
Accepted
21 Apr 2010
First published
25 May 2010

Chem. Commun., 2010,46, 4821-4823

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Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5′-monophosphate catalyzed by orotidine 5′-monophosphate decarboxylase

Y. Wu, C. Liao, C. Jen, Y. Shih and T. Chien, Chem. Commun., 2010, 46, 4821 DOI: 10.1039/C001865A

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