Issue 36, 2010
From the journal:

Chemical Communications

A facile scanometric strategy for ultrasensitive detection ofprotein using aptamer-initiated rolling circle amplification†

Wei Cheng,ab   Lin Ding,a   Yunlong Chen,a   Feng Yan,c   Huangxian Ju*ab  and  Yibing Yin*b  

* Corresponding authors

a Key Laboratory of Analytical Chemistry for Life Science (Ministry of Education of China), Department of Chemistry, Nanjing University, Nanjing 210093, P.R. China
E-mail: hxju@nju.edu.cn
Fax: 86 25 83593593
Tel: 86 25 83593593

b Laboratory of Laboratory Medical Diagnostics (Ministry of Education of China), Department of Key Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P.R. China

c Jiangsu Institute of Cancer Prevention and Cure, Nanjing 210009, P.R. China

Abstract

A pragmatic and simple strategy was developed for ultrasensitive detection of protein with good specificity and low matrix effect, which combined aptamer-initiated rolling circle amplification with a Au nanoparticle probe and convenient scanometric readout.

Graphical abstract: A facile scanometric strategy for ultrasensitive detection of protein using aptamer-initiated rolling circle amplification

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Article information

DOI
https://doi.org/10.1039/C002078H
Article type
Communication
Submitted
01 Feb 2010
Accepted
10 Aug 2010
First published
23 Aug 2010

Chem. Commun., 2010,46, 6720-6722

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A facile scanometric strategy for ultrasensitive detection of protein using aptamer-initiated rolling circle amplification

W. Cheng, L. Ding, Y. Chen, F. Yan, H. Ju and Y. Yin, Chem. Commun., 2010, 46, 6720 DOI: 10.1039/C002078H

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