Issue 30, 2010
From the journal:

Chemical Communications

Identifying drugmetallation sites on peptides using electron transfer dissociation (ETD), collision induced dissociation (CID) and ion mobility-mass spectrometry (IM-MS)†

Jonathan P. Williams,‡*a   Jeffery M. Brown,b   Iain Campuzanob  and  Peter J. Sadler*a  

* Corresponding authors

a Department of Chemistry, University of Warwick, Coventry, UK
E-mail: p.j.sadler@warwick.ac.uk
Fax: +44 (0)24 7652 3818

b Waters Corporation, Atlas Park Simonsway, Wythenshawe, Manchester, UK

Abstract

Electron transfer dissociation (ETD) and collision induced dissociation (CID) have been used to locate the precise binding sites for platinum and ruthenium anticancer complexes on the peptide Substance P. We show that ETD combined with ion mobility-mass spectrometry significantly reduces mass spectral complexity and improves the S/N of the product-ions formed.

Graphical abstract: Identifying drug metallation sites on peptides using electron transfer dissociation (ETD), collision induced dissociation (CID) and ion mobility-mass spectrometry (IM-MS)

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Article information

DOI
https://doi.org/10.1039/C0CC00358A
Article type
Communication
Submitted
12 Mar 2010
Accepted
05 May 2010
First published
27 May 2010

Chem. Commun., 2010,46, 5458-5460

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Identifying drug metallation sites on peptides using electron transfer dissociation (ETD), collision induced dissociation (CID) and ion mobility-mass spectrometry (IM-MS)

J. P. Williams, J. M. Brown, I. Campuzano and P. J. Sadler, Chem. Commun., 2010, 46, 5458 DOI: 10.1039/C0CC00358A

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