Issue 26, 2010
From the journal:

Chemical Communications

Electrosprayed core–shell microspheres for protein delivery

Yiquan Wu,*acd   I-Chien Liao,e   Scott J. Kennedy,cd   Jinzhi Du,f   Jun Wang,f   Kam W. Leonge  and  Robert L. Clarkbcd  

* Corresponding authors

a Materials Science Program, Department of Mechanical Engineering, University of Rochester, Rochester, New York 14627, USA
E-mail: wuyiquan@me.rochester.edu

b Department of Biomedical Engineering, University of Rochester, Rochester, New York 14627, USA

c Department of Mechanical Engineering and Material Science, Duke University, Durham, USA

d Center for Biologically Inspired Materials & Material Systems, Duke University, Durham, USA

e Department of Biomedical Engineering, Duke University, Durham, USA

f Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, People’s Republic of China

Abstract

This communication describes a single-step electrospraying technique that generates core–shell microspheres (CSMs) with encapsulated protein as the core and an amphiphilic biodegradable polymer as the shell. The protein release profiles of the electrosprayed CSMs showed steady release kinetics over 3 weeks without a significant initial burst.

Graphical abstract: Electrosprayed core–shell microspheres for protein delivery

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Article information

DOI
https://doi.org/10.1039/C0CC00535E
Article type
Communication
Submitted
22 Mar 2010
Accepted
05 May 2010
First published
20 May 2010

Chem. Commun., 2010,46, 4743-4745

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Electrosprayed core–shell microspheres for protein delivery

Y. Wu, I. Liao, S. J. Kennedy, J. Du, J. Wang, K. W. Leong and R. L. Clark, Chem. Commun., 2010, 46, 4743 DOI: 10.1039/C0CC00535E

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