Issue 30, 2010

Responsive polyelectrolyte complexes for triggered release of nucleic acid therapeutics

Abstract

The use of nucleic acids as therapeutics offers many potential benefits for treating disease. However, for these delicate yet potent biomolecules to be practical in the clinic, carrier vehicles are needed not only to protect the nucleic acids during transport in the body, but also release the biopolymers at the disease site. Polycations can meet the complex needs of nucleic acid delivery as they can condense the polyanionic nucleic acids to form stable polyelectrolyte complexes and, through appropriate design, can release the biotherapeutic at a target site. In this feature article, we review recent advances in the field, and indicate the ways in which future materials of this type might lead to enhanced therapies and treatments for currently untreatable diseases.

Graphical abstract: Responsive polyelectrolyte complexes for triggered release of nucleic acid therapeutics

Article information

Article type
Feature Article
Submitted
06 Apr 2010
Accepted
14 Jun 2010
First published
05 Jul 2010

Chem. Commun., 2010,46, 5421-5433

Responsive polyelectrolyte complexes for triggered release of nucleic acid therapeutics

M. Soliman, S. Allen, M. C. Davies and C. Alexander, Chem. Commun., 2010, 46, 5421 DOI: 10.1039/C0CC00794C

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