Issue 41, 2010
From the journal:

Chemical Communications

Gold(i) complex of N,N′-disubstituted cyclic thiourea with in vitro and in vivo anticancer properties—potent tight-binding inhibition of thioredoxin reductase†

Kun Yan,a   Chun-Nam Lok,a   Katarzyna Bierlab  and  Chi-Ming Che*a  

* Corresponding authors

a Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China
E-mail: cmche@hku.hk
Fax: (+852) 2857-1586

b CNRS/UPPA, Laboratory of Bio-Inorganic Analytical and Environmental Chemistry, UMR5254, Helioparc, 2 Av. Pr. Angot, F-64053, Pau, France

Abstract

Coinage metal complexes of an N,N′-disubstituted cyclic thiourea exert significant cytotoxicities to cancer cells and, in particular, the gold(I) thiourea complex exhibits a potent tight-binding inhibition of the anticancer drug target thioredoxin reductase with an inhibitory constant at nanomolar level.

Graphical abstract: Gold(i) complex of N,N′-disubstituted cyclic thiourea with in vitro and in vivo anticancer properties—potent tight-binding inhibition of thioredoxin reductase

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Article information

DOI
https://doi.org/10.1039/C0CC01058H
Article type
Communication
Submitted
21 Apr 2010
Accepted
14 Jun 2010
First published
09 Jul 2010

Chem. Commun., 2010,46, 7691-7693

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Gold(I) complex of N,N′-disubstituted cyclic thiourea with in vitro and in vivo anticancer properties—potent tight-binding inhibition of thioredoxin reductase

K. Yan, C. Lok, K. Bierla and C. Che, Chem. Commun., 2010, 46, 7691 DOI: 10.1039/C0CC01058H

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