Issue 30, 2010
From the journal:

Chemical Communications

A copperradiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(ii) complex that binds to amyloid-β plaques†

SinChun Lim,ab   Brett M. Paterson,ab   Michelle T. Fodero-Tavoletti,bcd   Graeme J. O'Keefe,e   Roberto Cappai,bc   Kevin J. Barnham,bcd   Victor L. Villemagne*de  and  Paul S. Donnelly*ab  

* Corresponding authors

a School of Chemistry, The University of Melbourne, Parkville, Victoria, Australia
E-mail: pauld@unimelb.edu.au

b Bio21 Institute, The University of Melbourne, Parkville, Victoria, Australia

c Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia

d The Mental Health Research Institute, Parkville, Melbourne, Victoria, Australia
E-mail: villemagne@petnm.unimelb.edu.au

e Centre for PET, Austin Hospital, Heidelberg, Melbourne, Victoria, Australia

Abstract

A bis(thiosemicarbazonato)copper(II) complex with an appended stilbene functional group binds to amyloid-β plaques that are associated with Alzheimer's disease. The complex has the potential to be of use as a copper-64 radiopharmaceutical to assist in the diagnosis of Alzheimer's disease by positron emission tomography.

Graphical abstract: A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(ii) complex that binds to amyloid-β plaques

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Article information

DOI
https://doi.org/10.1039/C0CC01175D
Article type
Communication
Submitted
29 Apr 2010
Accepted
01 Jun 2010
First published
17 Jun 2010

Chem. Commun., 2010,46, 5437-5439

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A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(II) complex that binds to amyloid-β plaques

S. Lim, B. M. Paterson, M. T. Fodero-Tavoletti, G. J. O'Keefe, R. Cappai, K. J. Barnham, V. L. Villemagne and P. S. Donnelly, Chem. Commun., 2010, 46, 5437 DOI: 10.1039/C0CC01175D

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