Iron-catalyzed regio- and stereoselective addition of acid chlorides to alkynes

Abstract

An iron-catalyzed regio- and stereoselective addition of acid chlorides to alkynes has been described. The reaction utilizes an inexpensive iron catalyst system and it is suitable for the formation of a variety of bifunctional molecules. This is an inexpensive, regio-, stereoselective and atom-economical approach to β-chloro-α,β-unsaturated ketones from simple and readily available starting materials.