Issue 41, 2010

The evolvability of lead peptides from small library screens

Abstract

Very little is known about the evolvability of lead peptides that are isolated from small library screens. Here we begin to explore this question by comparing the directed evolution of two peptides previously isolated from a small library screen to new ligands generated de novo by in vitro selection.

Graphical abstract: The evolvability of lead peptides from small library screens

Supplementary files

Article information

Article type
Communication
Submitted
18 May 2010
Accepted
11 Aug 2010
First published
09 Sep 2010

Chem. Commun., 2010,46, 7778-7780

The evolvability of lead peptides from small library screens

J. Zhang, B. A. R. Williams, M. T. Nilsson and J. C. Chaput, Chem. Commun., 2010, 46, 7778 DOI: 10.1039/C0CC01475C

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