Issue 39, 2010
From the journal:

Chemical Communications

Efficient receptor-independent intracellulartranslocation of aptamers mediated by conjugation to carbon nanotubes†

Jeroen Van den Bossche,a   Wafa' T. Al-Jamal,a   Bowen Tian,a   Antonio Nunes,a   Chiara Fabbro,b   Alberto Bianco,c   Maurizio Pratob  and  Kostas Kostarelos*a  

* Corresponding authors

a Nanomedicine Laboratory, Centre for Drug Delivery, The School of Pharmacy, University of London, 29-39 Brunswick Square, London, UK
E-mail: kostas.kostarelos@pharmacy.ac.uk
Fax: +44 (0)20 7757 5942
Tel: +44 (0)20 77535861

b Dipartimento di Scienze Farmaceutiche, Università di Trieste, 34127 Trieste, Italy

c CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunologie et Chimie Thérapeutiques, 67000 Strasbourg, France

Abstract

We have covalently grafted aptamers onto carboxylated carbon nanotubes to design a novel vector system that can easily translocate into the cytosol of different cell types independent of receptor-mediated uptake. We propose the use of carbon nanotubes for the efficient intracellular delivery of biologically active aptamers for potential therapeutic applications.

Graphical abstract: Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes

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Article information

DOI
https://doi.org/10.1039/C0CC02092C
Article type
Communication
Submitted
25 Jun 2010
Accepted
03 Aug 2010
First published
07 Sep 2010

Chem. Commun., 2010,46, 7379-7381

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Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes

J. V. D. Bossche, W. T. Al-Jamal, B. Tian, A. Nunes, C. Fabbro, A. Bianco, M. Prato and K. Kostarelos, Chem. Commun., 2010, 46, 7379 DOI: 10.1039/C0CC02092C

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