Issue 42, 2010
From the journal:

Chemical Communications

SERS mapping of nanoparticle labels in single cells using a microfluidic chip†

Christopher D. Syme,a   Narayana M. S. Sirimuthu,a   Shannon L. Faleyab  and  Jonathan M. Cooper*a  

* Corresponding authors

a Dept. of Electronics & Electrical Engineering, University of Glasgow, Glasgow, UK
E-mail: j.cooper@elec.gla.ac.uk

b Dept. of Biomedical Engineering and Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, USA

Abstract

We report for the first time the time-resolved mapping of intracellular nanoparticle labels from within living cells retained in a microstructured trap using Raman spectroscopy. The methods employed here also demonstrate the ability to rapidly discriminate between cell populations containing different SERS labels.

Graphical abstract: SERS mapping of nanoparticle labels in single cells using a microfluidic chip

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Article information

DOI
https://doi.org/10.1039/C0CC02209H
Article type
Communication
Submitted
29 Jun 2010
Accepted
23 Aug 2010
First published
21 Sep 2010

Chem. Commun., 2010,46, 7921-7923

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SERS mapping of nanoparticle labels in single cells using a microfluidic chip

C. D. Syme, N. M. S. Sirimuthu, S. L. Faley and J. M. Cooper, Chem. Commun., 2010, 46, 7921 DOI: 10.1039/C0CC02209H

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