Continuous-flow synthesis of vitamin D3

Shinichiro Fuse; Nobutake Tanabe; Masahito Yoshida; Hayato Yoshida; Takayuki Doi; Takashi Takahashi

doi:10.1039/C0CC02239J

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Continuous-flow synthesis of vitamin D₃†

Shinichiro Fuse,^a Nobutake Tanabe,^a Masahito Yoshida,^b Hayato Yoshida,^a Takayuki Doi^b and Takashi Takahashi*^a

Author affiliations

* Corresponding authors

^a Department of Applied Chemistry, Tokyo Institute of Technology, 2-12-1-H-101, Ookayama, Meguro-ku, Tokyo 152-8552, Japan
E-mail: ttak@apc.titech.ac.jp
Fax: +81 3-5734-2884
Tel: +81 3-5734-2120

^b Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aza-Aoba, Aramaki, Aoba, Sendai 980-8578, Japan

Abstract

A highly efficient, two-stage, continuous-flow synthesis of vitamin D₃ from provitamin D₃ was achieved. The developed method afforded the desired product in high yield (HPLC-UV: 60%, isolated: 32%) and required neither intermediate purification nor high-dilution conditions.

Download options Please wait...

Supplementary files

Experimental details PDF (394K)

Article information

DOI: https://doi.org/10.1039/C0CC02239J
Article type: Communication
Submitted: 30 Jun 2010
Accepted: 02 Sep 2010
First published: 28 Sep 2010

Download Citation

Chem. Commun., 2010,46, 8722-8724

Permissions

Request permissions

Continuous-flow synthesis of vitamin D₃

S. Fuse, N. Tanabe, M. Yoshida, H. Yoshida, T. Doi and T. Takahashi, Chem. Commun., 2010, 46, 8722 DOI: 10.1039/C0CC02239J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications