Issue 47, 2010

Tandem [4 + 1 + 1] annulation and metal-free aerobic oxidative aromatization: straightforward synthesis of highly substituted phenols from one aldehyde and two ketones

Abstract

Polysubstituted phenols are efficiently assembled from one aldehyde and two different methyl ketones in a one-pot operation via a newly base-induced regiospecific [4 + 1 + 1] annulation and sequential metal-free oxidative aromatization using molecular oxygen (from air) as the sole oxidant at room temperature.

Graphical abstract: Tandem [4 + 1 + 1] annulation and metal-free aerobic oxidative aromatization: straightforward synthesis of highly substituted phenols from one aldehyde and two ketones

Supplementary files

Article information

Article type
Communication
Submitted
01 Jul 2010
Accepted
29 Sep 2010
First published
25 Oct 2010

Chem. Commun., 2010,46, 9061-9063

Tandem [4 + 1 + 1] annulation and metal-free aerobic oxidative aromatization: straightforward synthesis of highly substituted phenols from one aldehyde and two ketones

M. Wang, Z. Fu, H. Feng, Y. Dong, J. Liu and Q. Liu, Chem. Commun., 2010, 46, 9061 DOI: 10.1039/C0CC02313B

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