Issue 40, 2010
From the journal:

Chemical Communications

Development of 5-silylethynyl-1,3-dioxolan-4-one as a new prochiral template for asymmetric phase-transfer catalysis†

Takuya Hashimoto,a   Kazuhiro Fukumoto,a   Naoyuki Abe,a   Kazuki Sakataa  and  Keiji Maruoka*a  

* Corresponding authors

a Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto, Japan
E-mail: maruoka@kuchem.kyoto-u.ac.jp
Fax: +81 75-753-4041
Tel: +81 75-753-4041

Abstract

Phase-transfer catalyzed asymmetric alkylation and Michael addition of 5-silylalkynyl-1,3-dioxolan-4-one were developed as a novel strategy to provide highly modular tertiary α-alkyl-α-hydroxy acids bearing an alkyne moiety.

Graphical abstract: Development of 5-silylethynyl-1,3-dioxolan-4-one as a new prochiral template for asymmetric phase-transfer catalysis

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Article information

DOI
https://doi.org/10.1039/C0CC02334E
Article type
Communication
Submitted
02 Jul 2010
Accepted
23 Aug 2010
First published
10 Sep 2010

Chem. Commun., 2010,46, 7593-7595

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Development of 5-silylethynyl-1,3-dioxolan-4-one as a new prochiral template for asymmetric phase-transfer catalysis

T. Hashimoto, K. Fukumoto, N. Abe, K. Sakata and K. Maruoka, Chem. Commun., 2010, 46, 7593 DOI: 10.1039/C0CC02334E

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