Issue 39, 2010
From the journal:

Chemical Communications

Development of photostable near-infrared cyanine dyes†

Animesh Samanta,a   Marc Vendrell,b   Rajkumar Dasa  and  Young-Tae Chang*ab  

* Corresponding authors

a Department of Chemistry & MedChem Program of Life Sciences Institute, National University of Singapore, Singapore
E-mail: chmcyt@nus.edu.sg
Fax: +65 6779 1691
Tel: +65 6516 6774

b Laboratory of Bioimaging Probe Development, Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), 11 Biopolis Way, #02-02 Helios Building, Singapore

Abstract

With the emerging interest in optical in vivo imaging, there is an increasing demand of photostable near-infrared (NIR) dyes. Herein we report the rational design of an amine tricarbocyanine structure with improved photostability (CyNA) and its combinatorial derivatization to render CyNA-414 as a NIR-fluorescent dye with stronger emission intensity and higher photostability than the NIR standard IndoCyanine Green (ICG).

Graphical abstract: Development of photostable near-infrared cyanine dyes

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Article information

DOI
https://doi.org/10.1039/C0CC02366C
Article type
Communication
Submitted
05 Jul 2010
Accepted
17 Aug 2010
First published
08 Sep 2010

Chem. Commun., 2010,46, 7406-7408

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Development of photostable near-infrared cyanine dyes

A. Samanta, M. Vendrell, R. Das and Y. Chang, Chem. Commun., 2010, 46, 7406 DOI: 10.1039/C0CC02366C

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