Issue 42, 2010

Synthesis of chiral tertiary trifluoromethyl alcohols by asymmetric nitroaldol reaction with a Cu(ii)-bisoxazolidine catalyst

Abstract

A highly enantioselective and diastereoselective copper(II)-bisoxazolidine catalyzed nitroaldol reaction with aliphatic and aromatic trifluoromethyl ketones is described.

Graphical abstract: Synthesis of chiral tertiary trifluoromethyl alcohols by asymmetric nitroaldol reaction with a Cu(ii)-bisoxazolidine catalyst

Supplementary files

Article information

Article type
Communication
Submitted
05 Jul 2010
Accepted
23 Aug 2010
First published
22 Sep 2010

Chem. Commun., 2010,46, 8026-8028

Synthesis of chiral tertiary trifluoromethyl alcohols by asymmetric nitroaldol reaction with a Cu(II)-bisoxazolidine catalyst

H. Xu and C. Wolf, Chem. Commun., 2010, 46, 8026 DOI: 10.1039/C0CC02378G

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