Issue 42, 2010
From the journal:

Chemical Communications

A novel bridged nucleoside bearing a conformationally switchable sugar moiety in response toredox changes†

Takeshi Baba,‡a   Tetsuya Kodama,‡a   Kazuto Mori,a   Takeshi Imanishia  and  Satoshi Obika*a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, Japan
E-mail: obika@phs.osaka-u.ac.jp
Fax: +81 6 6879 8204
Tel: +81 6 6879 8200

Abstract

A novel nucleoside analog with a disulfide bridge structure at the sugar moiety, which shows redox-responsive reversibility of the sugar conformation due to formation and scission of the disulfide bond, was designed and synthesized.

Graphical abstract: A novel bridged nucleoside bearing a conformationally switchable sugar moiety in response to redox changes

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Article information

DOI
https://doi.org/10.1039/C0CC02484H
Article type
Communication
Submitted
10 Jul 2010
Accepted
06 Sep 2010
First published
27 Sep 2010

Chem. Commun., 2010,46, 8058-8060

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A novel bridged nucleoside bearing a conformationally switchable sugar moiety in response to redox changes

T. Baba, T. Kodama, K. Mori, T. Imanishi and S. Obika, Chem. Commun., 2010, 46, 8058 DOI: 10.1039/C0CC02484H

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