Lateral flow nucleic acid biosensor for Cu2+ detection in aqueous solution with high sensitivity and selectivity

Zhiyuan Fang; Jing Huang; Puchang Lie; Zhuo Xiao; Chuanyan Ouyang; Qing Wu; Yixing Wu; Guodong Liu; Lingwen Zeng

doi:10.1039/C0CC02782K

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Lateral flow nucleic acid biosensor for Cu²⁺ detection in aqueous solution with high sensitivity and selectivity†

Zhiyuan Fang,‡^a Jing Huang,‡^ab Puchang Lie,^a Zhuo Xiao,^a Chuanyan Ouyang,^a Qing Wu,^a Yixing Wu,^c Guodong Liu*^d and Lingwen Zeng*^a

Author affiliations

* Corresponding authors

^a South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510663, China
E-mail: zeng6@yahoo.com

^b University of Science and Technology of China, Hefei, China

^c Department of Occupational Diseases, Guangzhou No.12 Hospital, Guangzhou, China

^d Department of Chemistry and Biochemistry, North Dakota StateUniversity, Fargo, USA
E-mail: guodong.liu@ndsu.edu

Abstract

A lateral flow nucleic acid biosensor based on copper-dependent DNA-cleaving DNAzyme and gold nanoparticles has been developed for the visual detection of copper ions (Cu²⁺) in an aqueous solution with a detection limit of 10 nM.

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Supplementary files

Reagents and materials, instruments, experimental procedures and conditions PDF (287K)

Article information

DOI: https://doi.org/10.1039/C0CC02782K
Article type: Communication
Submitted: 24 Jul 2010
Accepted: 15 Oct 2010
First published: 04 Nov 2010

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Chem. Commun., 2010,46, 9043-9045

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Lateral flow nucleic acid biosensor for Cu²⁺ detection in aqueous solution with high sensitivity and selectivity

Z. Fang, J. Huang, P. Lie, Z. Xiao, C. Ouyang, Q. Wu, Y. Wu, G. Liu and L. Zeng, Chem. Commun., 2010, 46, 9043 DOI: 10.1039/C0CC02782K

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Chemical Communications