Issue 41, 2010

Structural and biochemical basis for the firm chemo- and regioselectivity of the nitro-forming N-oxygenase AurF

Abstract

Site-directed mutagenesis based on the crystal structure of AurF, a nitro group forming monooxygenase from Streptomyces thioluteus, revealed that AurF variants are capable of selectively transforming guanidyl- and amidinyl-substituted anilines into the corresponding nitro compounds. Our results provide new insights into the biochemical basis of regioselective N-oxygenation.

Graphical abstract: Structural and biochemical basis for the firm chemo- and regioselectivity of the nitro-forming N-oxygenase AurF

Supplementary files

Article information

Article type
Communication
Submitted
26 Jul 2010
Accepted
13 Aug 2010
First published
08 Sep 2010

Chem. Commun., 2010,46, 7760-7762

Structural and biochemical basis for the firm chemo- and regioselectivity of the nitro-forming N-oxygenase AurF

A. Fries, R. Winkler and C. Hertweck, Chem. Commun., 2010, 46, 7760 DOI: 10.1039/C0CC02811H

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